Proceedings Vol. 17 (2011)
ENGINEERING MECHANICS 2011
May 9 – 12, 2011, Svratka, Czech Republic
Copyright © 2011 Institute of Thermomechanics, Academy of Sciences of the Czech Republic, v.v.i., Prague
ISSN 1805-8248 (printed)
ISSN 1805-8256 (electronic)
list of papers scientific commitee
pages 451 - 454, full text
In this paper, a new description of intracellular Ca2+ dynamics in the model of rat ventricular cardiomyocyte is presented. The principal modifications based on the recently published data comprise: formulation of the function of peripheral dyads, incorporation of peripheral and tubular intracellular subspaces, reformulation of inactivation properties of surface of tubular ICa and description of the function of exogenous Ca2+ buffer in intracellular space. The modified model will be used to explore the activity induced ion-concentration changes in rat transverse-axial tubular system in a more detail and to investigate their effects on excitation – contraction coupling in ventricular cardiomyocytes.
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