Engineering Mechanics

International Conference

Proceedings Vol. 8 (2002)



May 13 – 16, 2002, Svratka, Czech Republic
Editors: Lubomír Houfek, Pavel Hlavoň, Petr Krejčí

Copyright © 2002 Institute of Mechanics of Solids, Faculty of Mechanical Engineering, Bruno University of Technology, Brno

ISBN 80-214-2109-6 (printed)
ISSN 1805-8248 (printed)
ISSN 1805-8256 (electronic)

list of papers scientific commitee

Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells: development of model
M. Pásek, G. Christé, J. Šimurda
pages 207 - +8p., full text

The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27J, the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations.

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All papers were reviewed by members of the scientific committee.

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