Proceedings Vol. 8 (2002)
INŽENÝRSKÁ MECHANIKA 2002
ENGINEERING MECHANICS 2002
May 13 – 16, 2002, Svratka, Czech Republic
Copyright © 2002 Institute of Mechanics of Solids, Faculty of Mechanical Engineering, Bruno University of Technology, Brno
ISSN 1805-8248 (printed)
ISSN 1805-8256 (electronic)
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pages 207 - +8p., full text
The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27J, the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations.
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