Engineering Mechanics

International Conference

Proceedings Vol. 26 (2020)


ENGINEERING MECHANICS 2020

26th INTERNATIONAL CONFERENCE
November 24 – 25, 2020, Brno, Czech Republic
;
Editors: Vladimír Fuis

Copyright © 2020 Brno University of Technology Institute of Solid Mechanics, Mechatronics and Biomechanics

ISBN 978-80-214-5896-3 (printed)
ISSN 1805-8248 (printed)
ISSN 1805-8256 (electronic)

list of papers scientific commitee

FINITE ELEMENT MODELS OF MECHANICAL BEHAVIOUR OF ENDOTHELIAL CELLS
Jakka Veera V. S. V. P., Burša J.
pages 222 - 225, full text

Recently hybrid models of the endothelial cell were created by using the bendo-tensegrity concept to complete the continuum parts of the cell with an adequate cytoskeleton model. The proposed model of endothelial cell includes a network of actin filaments (AFs) as tension supporting cables and microtubules (MTs) as bended beams supporting primarily compression. It is created by adopting the geometrical shape of a short hexagonal prism with its 12 vertices that results in a nearly isotropic behaviour of the model without a preferred orientation. To achieve the synergistic effect of cytoskeletal components, the elements representing AFs, MTs, and Intermediate filaments (IFs) are sharing the same end nodes (representing focal adhesions) with the cell membrane (CM). The AFs are prestressed (i.e. stressed without application of external load), which is essential for the cell shape stability, while the IFs are wavy, thus not bearing load until straightened. The objective is to create different FE models of endothelial cells which will be used to simulate mechanical responses of the cell under different loading conditions. Endothelial cell dysfunction has been linked to atherosclerosis through their response to mechanical loads, especially hemodynamic forces.


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Ownership of copyright in original research articles remains with the Authors, and provided that, when reproducing parts of the contribution, the Authors acknowledge and/or reference the Proceedings, the Authors do not need to seek permission for re-use of their material.

All papers were reviewed by members of the scientific committee.


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