Engineering Mechanics

International Conference

Proceedings Vol. 27/28 (2022)


May 9 – 12, 2022, Milovy, Czech Republic
Editors: Cyril Fischer and Jiří Náprstek

Copyright © 2022 Institute of Theoretical and Applied Mechanics of the Czech Academy of Sciences, Prague

ISBN 978-80-86246-48-2 (printed)
ISBN 978-80-86246-51-2 (electronic)
ISSN 1805-8248 (printed)
ISSN 1805-8256 (electronic)

list of papers scientific commitee

The impact of the mitochondrial network on the mechanical response of diseased animal cell
Orlová L., Gumulec J., Burša J.
pages 297 - 300, full text

Understanding the cell mechanics during cancer progression is potentially relevant for cancer diagnosis and treatment. As a consequence of metabolic reprogramming in cancer cells, mitochondrial fusion and fission are altered which causes a reorganization in the mitochondrial network. A relation between such reorganization and the cell response to mechanical stimuli calls for further investigation because mitochondria could thus prove to be a significant therapeutic target. A computational simulation of an indentation test using a structural cell model incorporating a realistic mitochondrial network indicates a significant impact of mitochondria on the overall response of the cell.

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Ownership of copyright in original research articles remains with the Authors, and provided that, when reproducing parts of the contribution, the Authors acknowledge and/or reference the Proceedings, the Authors do not need to seek permission for re-use of their material.

All papers were reviewed by members of the scientific committee.

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